A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry
Identifieur interne : 001283 ( Main/Corpus ); précédent : 001282; suivant : 001284A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry
Auteurs : Mona K. Beyer ; Carmen C. Janvin ; Jan P. Larsen ; Dag AarslandSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2007-03.
English descriptors
- KwdEn :
- ANCOVA, analysis of covariance, ANOVA, analysis of variance, FWE, family-wise error, MCI, mild cognitive impairment, MMSE, Mini-Mental State Examination, MRI, magnetic resonance imaging, PDD, Parkinson’s disease with dementia, PDND, Parkinson’s disease without dementia, SPM, statistical parametric mapping, SVC, small volume correction, VBM, voxel-based morphometry.
Abstract
Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.
Url:
DOI: 10.1136/jnnp.2006.093849
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C" last="Janvin">Carmen C. Janvin</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name><affiliation><mods:affiliation>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1136/jnnp.2006.093849</idno><idno type="url">https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001283</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><author><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K" last="Beyer">Mona K. Beyer</name><affiliation><mods:affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Janvin, Carmen C" sort="Janvin, Carmen C" uniqKey="Janvin C" first="Carmen C" last="Janvin">Carmen C. Janvin</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P" last="Larsen">Jan P. Larsen</name><affiliation><mods:affiliation>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author><author><name sortKey="Aarsland, Dag" sort="Aarsland, Dag" uniqKey="Aarsland D" first="Dag" last="Aarsland">Dag Aarsland</name><affiliation><mods:affiliation>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2007-03">2007-03</date><biblScope unit="volume">78</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="254">254</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</idno><idno type="DOI">10.1136/jnnp.2006.093849</idno><idno type="href">jnnp-78-254.pdf</idno><idno type="PMID">17028119</idno><idno type="local">0780254</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ANCOVA, analysis of covariance</term><term>ANOVA, analysis of variance</term><term>FWE, family-wise error</term><term>MCI, mild cognitive impairment</term><term>MMSE, Mini-Mental State Examination</term><term>MRI, magnetic resonance imaging</term><term>PDD, Parkinson’s disease with dementia</term><term>PDND, Parkinson’s disease without dementia</term><term>SPM, statistical parametric mapping</term><term>SVC, small volume correction</term><term>VBM, voxel-based morphometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>Mona K Beyer</name><affiliations><json:string>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Carmen C Janvin</name><affiliations><json:string>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Jan P Larsen</name><affiliations><json:string>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item><json:item><name>Dag Aarsland</name><affiliations><json:string>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Papers</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (neurology)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stroke</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Memory disorders (psychiatry)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Radiology (diagnostics)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ANCOVA, analysis of covariance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ANOVA, analysis of variance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>FWE, family-wise error</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MCI, mild cognitive impairment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MMSE, Mini-Mental State Examination</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI, magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PDD, Parkinson’s disease with dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>PDND, Parkinson’s disease without dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SPM, statistical parametric mapping</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>SVC, small volume correction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>VBM, voxel-based morphometry</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</abstract><qualityIndicators><score>7.628</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>17</keywordCount><abstractCharCount>1455</abstractCharCount><pdfWordCount>5099</pdfWordCount><pdfCharCount>33216</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>219</abstractWordCount></qualityIndicators><title>A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><pmid><json:string>17028119</json:string></pmid><genre><json:string>research-article</json:string></genre><host><volume>78</volume><pages><first>254</first></pages><issn><json:string>0022-3050</json:string></issn><issue>3</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-330X</json:string></eissn><title>Journal of Neurology, Neurosurgery & Psychiatry</title></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1136/jnnp.2006.093849</json:string></doi><id>1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><respStmt xml:id="ISTEX-API" resp="Références bibliographiques récupérées via GROBID" name="ISTEX-API (INIST-CNRS)"></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2006-10-06</date></publicationStmt><notesStmt><note>Correspondence to:
Dr Mona K Beyer
Department of Radiology, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway; bemk@sus.no</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title><author><persName><forename type="first">Mona K</forename><surname>Beyer</surname></persName><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Carmen C</forename><surname>Janvin</surname></persName><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Jan P</forename><surname>Larsen</surname></persName><affiliation>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation></author><author><persName><forename type="first">Dag</forename><surname>Aarsland</surname></persName><affiliation>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</affiliation></author></analytic><monogr><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="pISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2007-03"></date><biblScope unit="volume">78</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="254">254</biblScope></imprint></monogr><idno type="istex">1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</idno><idno type="DOI">10.1136/jnnp.2006.093849</idno><idno type="href">jnnp-78-254.pdf</idno><idno type="PMID">17028119</idno><idno type="local">0780254</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006-10-06</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</p></abstract><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Memory disorders (neurology)</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Stroke</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Memory disorders (psychiatry)</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Radiology</term></item></list></keywords></textClass><textClass><keywords scheme="keyword"><list><head>hwp-journal-coll</head><item><term>Radiology (diagnostics)</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>ANCOVA, analysis of covariance</term></item><item><term>ANOVA, analysis of variance</term></item><item><term>FWE, family-wise error</term></item><item><term>MCI, mild cognitive impairment</term></item><item><term>MMSE, Mini-Mental State Examination</term></item><item><term>MRI, magnetic resonance imaging</term></item><item><term>PDD, Parkinson’s disease with dementia</term></item><item><term>PDND, Parkinson’s disease without dementia</term></item><item><term>SPM, statistical parametric mapping</term></item><item><term>SVC, small volume correction</term></item><item><term>VBM, voxel-based morphometry</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-10-06">Created</change><change when="2007-03">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">0780254</article-id><article-id pub-id-type="doi">10.1136/jnnp.2006.093849</article-id><article-id pub-id-type="other">jnnp;78/3/254</article-id><article-id pub-id-type="other">jnnp;jnnp.2006.093849</article-id><article-id pub-id-type="pmid">17028119</article-id><article-id pub-id-type="other">254</article-id><article-id pub-id-type="other">jnnp.2006.093849</article-id><article-categories><subj-group subj-group-type="heading"><subject content-type="original">Papers</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (neurology)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Stroke</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Memory disorders (psychiatry)</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>Radiology (diagnostics)</subject></subj-group></article-categories><title-group><article-title>A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Beyer</surname><given-names>Mona K</given-names></name><xref rid="AFF1">1</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Janvin</surname><given-names>Carmen C</given-names></name><xref rid="AFF2">2</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Larsen</surname><given-names>Jan P</given-names></name><xref rid="AFF3">3</xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Aarsland</surname><given-names>Dag</given-names></name><xref rid="AFF4">4</xref></contrib><aff id="AFF1"><label>1</label>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</aff><aff id="AFF2"><label>2</label>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</aff><aff id="AFF3"><label>3</label>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</aff><aff id="AFF4"><label>4</label>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</aff></contrib-group><author-notes><corresp>Correspondence to:
Dr Mona K Beyer
Department of Radiology, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway; <ext-link xlink:href="bemk@sus.no" ext-link-type="email" xlink:type="simple">bemk@sus.no</ext-link></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2007</year></pub-date><pub-date pub-type="epub"><day>6</day><month>10</month><year>2006</year></pub-date><volume>78</volume><volume-id pub-id-type="other">78</volume-id><volume-id pub-id-type="other">78</volume-id><issue>3</issue><issue-id pub-id-type="other">jnnp;78/3</issue-id><issue-id pub-id-type="other">3</issue-id><issue-id pub-id-type="other">78/3</issue-id><fpage>254</fpage><history><date date-type="accepted"><day>27</day><month>09</month><year>2006</year></date><date date-type="received"><day>21</day><month>03</month><year>2006</year></date><date date-type="rev-recd"><day>24</day><month>08</month><year>2006</year></date></history><permissions><copyright-statement>Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</copyright-statement><copyright-year>2007</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-78-254.pdf"></self-uri><abstract xml:lang="en"><p><bold>Background:</bold> Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood.</p><p><bold>Aim:</bold> To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging.</p><p><bold>Methods:</bold> Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used.</p><p><bold>Results:</bold> Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found.</p><p><bold>Conclusion:</bold> These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</p></abstract><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>ANCOVA, analysis of covariance</kwd><kwd>ANOVA, analysis of variance</kwd><kwd>FWE, family-wise error</kwd><kwd>MCI, mild cognitive impairment</kwd><kwd>MMSE, Mini-Mental State Examination</kwd><kwd>MRI, magnetic resonance imaging</kwd><kwd>PDD, Parkinson’s disease with dementia</kwd><kwd>PDND, Parkinson’s disease without dementia</kwd><kwd>SPM, statistical parametric mapping</kwd><kwd>SVC, small volume correction</kwd><kwd>VBM, voxel-based morphometry</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry</title></titleInfo><name type="personal"><namePart type="given">Mona K</namePart><namePart type="family">Beyer</namePart><affiliation>Department of Radiology, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmen C</namePart><namePart type="family">Janvin</namePart><affiliation>Department of Geriatric Psychiatry, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan P</namePart><namePart type="family">Larsen</namePart><affiliation>Department of Neurology, Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dag</namePart><namePart type="family">Aarsland</namePart><affiliation>Department of Geriatric Psychiatry, Centre for Clinical Neuroscience Research, Stavanger University Hospital, Stavanger, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (neurology)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Stroke</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Memory disorders (psychiatry)</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology</topic></subject><subject><genre>hwp-journal-coll</genre><topic>Radiology (diagnostics)</topic></subject><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2007-03</dateIssued><dateCreated encoding="w3cdtf">2006-10-06</dateCreated><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Background: Dementia is common in Parkinson’s disease, but the underlying brain pathology is not yet fully understood. Aim: To examine the changes in the brain of patients with Parkinson’s disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. Methods: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson’s disease and dementia (PDD; n = 16) and Parkinson’s disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. Results: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. Conclusion: These findings show that dementia in Parkinson’s disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.</abstract><note type="author-notes">Correspondence to:
Dr Mona K Beyer
Department of Radiology, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway; bemk@sus.no</note><subject lang="en"><genre>ABR</genre><topic>ANCOVA, analysis of covariance</topic><topic>ANOVA, analysis of variance</topic><topic>FWE, family-wise error</topic><topic>MCI, mild cognitive impairment</topic><topic>MMSE, Mini-Mental State Examination</topic><topic>MRI, magnetic resonance imaging</topic><topic>PDD, Parkinson’s disease with dementia</topic><topic>PDND, Parkinson’s disease without dementia</topic><topic>SPM, statistical parametric mapping</topic><topic>SVC, small volume correction</topic><topic>VBM, voxel-based morphometry</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>254</start></extent></part></relatedItem><identifier type="istex">1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5</identifier><identifier type="DOI">10.1136/jnnp.2006.093849</identifier><identifier type="href">jnnp-78-254.pdf</identifier><identifier type="PMID">17028119</identifier><identifier type="local">0780254</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright 2007 Journal of Neurology Neurosurgery and Psychiatry</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><annexes><json:item><original>true</original><mimetype>image/jpeg</mimetype><extension>jpeg</extension><uri>https://api.istex.fr/document/1ADAFFBBAA32E7891E9A8A46FB9D950A0E55FCF5/annexes/jpeg</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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